Published Research

Our researchers and staff have published a large body of high-quality research on cancer and chronic kidney disease, as well as other health topics such as screening, survivorship, palliative care, sustainability, equity and health services.

For a list of our journal articles, visit PubMed.

Featured CCO Research Articles

Apostolovski S, McCallum F, Simniceanu C, Kraus J, Gutierrez E, Liszewski B, Esselink E, Bissonnette JP, Hart M, Brundage M, Warde P, Pantarotto J. A Clinical Consensus Approach to Developing a New Funding Model for Radiation Services in Ontario. Healthc Q. 2023 Jul;26(2):37-42. doi: 10.12927/hcq.2023.27146. PMID: 37572070.

Dai WF, Habbous S, Saluja R, Beca J, Raphael M, Arias J, Gavura S, Earle CC, Biagi JJ, Coburn N, Chan KK. Comparative Effectiveness of FOLFIRINOX versus Gemcitabine and Nab-paclitaxel in Initially Unresectable Locally Advanced Pancreatic Cancer: a Population-based Study to Assess Subsequent Surgical Resection and Overall Survival. Clin Oncol (R Coll Radiol). 2023 May;35(5):e303-e311. doi: 10.1016/j.clon.2023.02.008. Epub 2023 Feb 16. PMID: 36863956.

DeBono NL, Daniels RD, Beane Freeman LE, Graber JM, Hansen J, Teras LR, Driscoll T, Kjaerheim K, Demers PA, Glass DC, Kriebel D, Kirkham TL, Wedekind R, Filho AM, Stayner L, Schubauer-Berigan MK. Firefighting and Cancer: A Meta-analysis of Cohort Studies in the Context of Cancer Hazard Identification. Saf Health Work. 2023 Jun;14(2):141-152. doi: 10.1016/j.shaw.2023.02.003. Epub 2023 Mar 7. PMID: 37389311.

Evans WK, Tammemägi MC, Walker MJ, Cameron E, Leung YW, Ashton S, de Loë J, Doyle W, Bornais C, Allie E, Alkema K, Bravo CA, McGarry C, Rey M, Truscott R, Darling G, Rabeneck L. Integrating smoking cessation into LDCT lung cancer screening: Results of the Ontario, Canada Pilot. J Thorac Oncol. 2023 Jul 6:S1556-0864(23)00669-X. doi: 10.1016/j.jtho.2023.07.004. Epub ahead of print. PMID: 37422265.

Fu R, Sutradhar R, Li Q, Kamalraj P, Dare A, Hanna TP, Chan KKW, Irish JC, Coburn N, Hallet J, Singh S, Parmar A, Earle CC, Lapointe-Shaw L, Krzyzanowska MK, Louie AV, Mahar A, Urbach DR, McIsaac DI, Enepekides D, Gomez D, Look Hong NJ, Tinmouth J, Eskander A. Early survival for patients newly diagnosed with cancer during COVID-19 in Ontario, Canada: A population-based cohort study. Cancer Med. 2023 May;12(10):11849-11859. doi: 10.1002/cam4.5861. Epub 2023 Mar 31. PMID: 36999960.

Gupta S, Li Q, Nathan PC, D'Agostino N, Baxter NN, Fox C, Chalifour K, Coburn N, Sutradhar R. Prevalence, severity, and predictors of symptom burden among adolescents and young adults with cancer. Cancer Med. 2023 May;12(10):11773-11785. doi: 10.1002/cam4.5837. Epub 2023 Mar 27. PMID: 36970969.

Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4; Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration. The association between genetically elevated polyunsaturated fatty acids and risk of cancer. EBioMedicine. 2023 May;91:104510. doi: 10.1016/j.ebiom.2023.104510. Epub 2023 Apr 20. PMID: 37086649.

Kelly-Reif K, Bertke SJ, Rage E, Demers PA, Fenske N, Deffner V, Kreuzer M, Samet J, Schubauer-Berigan MK, Tomasek L, Zablotska LB, Wiggins C, Laurier D, Richardson DB. Radon and lung cancer in the pooled uranium miners analysis (PUMA): highly exposed early miners and all miners. Occup Environ Med. 2023 Jul;80(7):385-391. doi: 10.1136/oemed-2022-108532. Epub 2023 May 10. PMID: 37164624.

Lapointe J, Côté JM, Mbuya-Bienge C, Dorval M, Pashayan N, Chiquette J, Eloy L, Turgeon A, Lambert-Côté L, Brooks JD, Walker MJ, Blackmore KM, Joly Y, Knoppers BM, Chiarelli AM, Simard J, Nabi H. Canadian Healthcare Professionals' Views and Attitudes toward Risk-Stratified Breast Cancer Screening. J Pers Med. 2023 Jun 21;13(7):1027. doi: 10.3390/jpm13071027. PMID: 37511640.

Mavaddat N, Ficorella L, Carver T, Lee A, Cunningham AP, Lush M, Dennis J, Tischkowitz M, Downes K, Hu D, Hahnen E, Schmutzler RK, Stockley TL, Downs GS, Zhang T, Chiarelli AM, Bojesen SE, Liu C, Chung WK, Pardo M, Feliubadaló L, Balmaña J, Simard J, Antoniou AC, Easton DF. Incorporating alternative Polygenic Risk Scores into the BOADICEA breast cancer risk prediction model. Cancer Epidemiol Biomarkers Prev. 2023 Mar 6;32(3):422-427. doi: 10.1158/1055-9965.EPI-22-0756. PMID: 36649146.

Metser U, Kulanthaivelu R, Salawu A, Razak A, Mak V, Li X, Langer DL, MacCrostie P, Singunkar A. [18F]FDG PET/CT in the Initial Staging and Restaging of Soft-Tissue or Bone Sarcoma in Patients with Negative or Equivocal Findings for Metastases or Limited Recurrence on Conventional Work-up: Results of a Prospective Multicenter Registry. J Nucl Med. 2023 Jul 6:jnumed.122.265278. doi: 10.2967/jnumed.122.265278. Epub ahead of print. PMID: 37414444.

Milgram L, Wheeler S, Adamic A, Loncar M, Guirguis M, McCabe BJ. A Framework for Evaluating the Implementation of Biosimilar Drugs. Can J Hosp Pharm. 2023 Mar 1;76(2):109-116. doi: 10.4212/cjhp.3272. PMID: 36998755

Milroy S, Wong J, Eberg M, Ieraci L, Forster K, Holloway CMB, Sutherland JM. Associations between Clinical Pathway Concordance, Cost and Survival Outcomes for Stage II Colon Cancer: A Population-based Study. Int J Qual Health Care. 2023 Apr 5;35(2):mzad012. doi: 10.1093/intqhc/mzad012. PMID: 36961746.

Muradali D, Fletcher GG, Cordeiro E, Fienberg S, George R, Kulkarni S, Seely JM, Shaheen R, Eisen A. Preoperative Breast Magnetic Resonance Imaging: An Ontario Health (Cancer Care Ontario) Clinical Practice Guideline. Curr Oncol. 2023 Jun 30;30(7):6255-6270. doi: 10.3390/curroncol30070463. PMID: 37504323.

Naipaul R, Marques C, Ng J, Barbour S, Lo C, Hildebrand AM, Siu V, Prasad B, Laurin LP, Wazny LD, Armstrong S, Tran J, Sheffield M, Jauhal A, Hladunewich MA. Focused Jurisdictional Scan of Glomerulonephritis Medication Access in Canada: A Program Report. Can J Kidney Health Dis. 2023 Aug 12;10:20543581231190227. doi: 10.1177/20543581231190227. PMID: 37581108

Naylor KL, McArthur E, Dixon SN, Kwong JC, Thomas D, Balamchi S, Blake PG, Garg AX, Atiqazaaman M, Hladunewich MA, Levin A, Yeung A, Oliver MJ. Impact of study design on vaccine effectiveness estimates of two mRNA COVID-19 vaccine doses in patients with stage 5 chronic kidney disease. Kidney Int. 2023 Apr;103(4):791-797. doi: 10.1016/j.kint.2023.01.009. Epub 2023 Jan 31. PMID: 36731610.

Parmar A, Dai WF, Dionne F, Geirnaert M, Denburg A, Ahuja T, Beca J, Bouchard S, Chambers C, Hunt MJ, Husereau D, Lungu L, McDonald V, Mercer RE, Mitera G, Muñoz C, Naipaul R, Peacock S, Potashnik T, Tadrous M, Takhar P, Taylor M, Trudeau M, Wasney D, Gavura C, Chan KKW. Development of a Multi-Criteria Decision Analysis Rating Tool to Prioritize Real-World Evidence Questions for the Canadian Real-World Evidence for Value of Cancer Drugs (CanREValue) Collaboration. Curr Oncol. 2023 Mar 28;30(4):3776-3786. doi: 10.3390/curroncol30040286. PMID: 37185399.

Roushani J, Thomas D, Oliver MJ, Ip J, Yeung A, Tang Y, Brimble KS, Levin A, Hladunewich MA, Cooper R, Blake PG. Clinical Outcomes and Vaccine Effectiveness for SARS-CoV-2 Infection in People Attending Advanced CKD Clinics. Clin J Am Soc Nephrol. 2023 Apr 1;18(4):465-474. doi: 10.2215/CJN.0000000000000087. Epub 2023 Feb 16. PMID: 36795940.

Sue-Chue-Lam C, Castelo M, Benmessaoud A, Kishibe T, Llovet D, Brezden-Masley C, Yu AY, Tinmouth J, Baxter NN. Randomised controlled trials of non-pharmacological interventions to improve patient-reported outcomes of colonoscopy: a scoping review. BMJ Open Gastroenterol. 2023 Jun;10(1):e001129. doi: 10.1136/bmjgast-2023-001129. PMID: 37277204.

Wright FC, Milkovich J, Hunter A, Darling G, Irish J. Refining the thoracic surgical oncology regionalization standards for esophageal surgery in Ontario, Canada: Moving from good to better. J Thorac Cardiovasc Surg. 2023 Mar 10:S0022-5223(23)00191-5. doi: 10.1016/j.jtcvs.2023.03.002. Epub ahead of print. PMID: 37005118.

Yau K, Enilama O, Levin A, Romney MG, Singer J, Blake P, Perl J, Leis JA, Kozak R, Tsui H, Bolotin S, Tran V, Chan CT, Tam P, Dhruve M, Kandel C, Estrada-Codecido J, Brown T, Siwakoti A, Abe KT, Hu Q, Colwill K, Gingras AC, Oliver MJ, Hladunewich MA. Determining the Longitudinal Serologic Response to COVID-19 Vaccination in the Chronic Kidney Disease Population: A Clinical Research Protocol. Can J Kidney Health Dis. 2023 Mar 20;10:20543581231160511. doi: 10.1177/20543581231160511. PMID: 36950028.

Yohanna S, Naylor KL, Luo B, Dixon SN, Bota SE, Kim SJ, Blake PG, Elliott L, Cooper R, Knoll GA, Treleaven D, Wang C, Garg AX. Variation in Kidney Transplant Referral Across Chronic Kidney Disease Programs in Ontario, Canada. Can J Kidney Health Dis. 2023 Jun 14;10:20543581231169608. doi: 10.1177/20543581231169608. PMID: 37359986,

Articles by external researchers utilizing CCO data

AlGhamdi S, Kong W, Brundage M, Eisenhauer EA, Parker CM, Digby GC. Characterizing Variability in Lung Cancer Outcomes and Influence of a Lung Diagnostic Assessment Program in Southeastern Ontario, Canada. Curr Oncol. 2023 May 9;30(5):4880-4896. doi: 10.3390/curroncol30050368. PMID: 37232826.

Al-Jaishi AA, Jeyakumar N, Kang Y, De Chickera S, Dixon SN, Luo B, Sontrop J, Walsh M, Tonelli M, Garg AX. Health Services Use and Outcomes for Hospital Admissions With a Major Cardiovascular Event Recorded in Health Care Administrative Data in Patients Receiving Maintenance Hemodialysis: A Retrospective Cohort Study. Can J Kidney Health Dis. 2023 Apr 13;10:20543581231165708. doi: 10.1177/20543581231165708. PMID: 37065967

Cairncross ZF, Shack L, Nelson G, Friedenreich CM, Ray J, Fell DB, Lisonkova S, Bhatti P, Sikdar K, McMorris C, Metcalfe A. Long-term Mortality in Individuals Diagnosed With Cancer During Pregnancy or Postpartum. JAMA Oncol. 2023 Jun 1;9(6):791-799. doi: 10.1001/jamaoncol.2023.0339. PMID: 37022714.

Castelo M, Paszat L, Hansen BE, Scheer AS, Faught N, Nguyen L, Baxter NN. Analysis of Time to Treatment and Survival Among Adults Younger Than 50 Years of Age With Colorectal Cancer in Canada. JAMA Netw Open. 2023 Aug 1;6(8):e2327109. doi: 10.1001/jamanetworkopen.2023.27109. PMID: 37535356.

Castelo M, Sutradhar R, Faught N, Mata DGMM, Hahn E, Nguyen L, Paszat L, Rodin D, Trebinjac S, Fong C, Rakovitch E. The Association Between Surgical Axillary Staging, Adjuvant Treatment Use and Survival in Older Women with Early Stage Breast Cancer: A Population-Based Study. Ann Surg Oncol. 2023 Jul;30(7):3901-3912. doi: 10.1245/s10434-023-13274-0. Epub 2023 Mar 14. PMID: 36917335.

Ethier JL, Kong W, MacKay HJ, McGee J, Booth CM.

Real-world outcomes associated with use of front-line bevacizumab in ovarian cancer. J Cancer Policy. 2023 Jun;36:100421. doi: 10.1016/j.jcpo.2023.100421. Epub 2023 Apr 7. PMID: 37030536.

Giannakeas V, Murji A, Lipscombe LL, Narod SA, Kotsopoulos J. Salpingectomy and the Risk of Ovarian Cancer in Ontario. JAMA Netw Open. 2023 Aug 1;6(8):e2327198. doi: 10.1001/jamanetworkopen.2023.27198. PMID: 37566421.

Gold N, Christensen RAG, Arneja J, Aminoleslami A, Anderson GM, Brooks JD. Screening behaviours, demographics, and stage at diagnosis in the publicly funded Ontario Breast Screening Program. Breast Cancer Res Treat. 2023 Apr;198(3):523-533. doi: 10.1007/s10549-022-06848-1. Epub 2023 Feb 17. PMID: 36800117.

Gong I, Cheung MC, Chan KKW, Arya S, Faught N, Calzavara A, Liu N, Odejide OO, Abel G, Kurdyak P, Raphael MJ, Kuczmarski T, Prica A, Mozessohn L. Mortality among patients with diffuse large B-cell lymphoma with mental disorders: a population-based study. J Natl Cancer Inst. 2023 Aug 2:djad149. doi: 10.1093/jnci/djad149. Epub ahead of print. PMID: 37531271.

Kuruvilla J, Ewara EM, Elia-Pacitti J, Ng R, Eberg M, Kukaswadia A, Sharma A. Estimating the Burden of Illness of Relapsed Follicular Lymphoma and Marginal Zone Lymphoma in Ontario, Canada. Curr Oncol. 2023 Apr 30;30(5):4663-4676. doi: 10.3390/curroncol30050352. PMID: 37232810.

Kwon JY, Kopec J, Sutherland JM, Lambert LK, Anis AH, Sawatzky R. Patient-reported mental health and well-being trajectories in oncology patients during radiation therapy: an exploratory retrospective cohort analysis using the Ontario Cancer Registry. Qual Life Res. 2023 May 4. doi: 10.1007/s11136-023-03430-0. Epub ahead of print. PMID: 37140774.

Mah SJ, Carter Ramirez DM, Eiriksson LR, Schnarr K, Gayowsky A, Seow H. Palliative care utilization across health sectors for patients with gynecologic malignancies in Ontario, Canada from 2006 to 2018. Gynecol Oncol. 2023 Aug;175:169-175. doi: 10.1016/j.ygyno.2023.06.016. Epub 2023 Jun 29. PMID: 37392530.

Moldaver DM, Hassan S, Seung SJ, Edwin J, Clouthier DL, Vera-Badillo FE. A real-world retrospective analysis of the management of metastatic castrate-resistant prostate cancer in Ontario, Canada from 2010 - 2018. Urol Oncol. 2023 Mar;41(3):146.e13-146.e22. doi: 10.1016/j.urolonc.2022.11.019. Epub 2023 Jan 12. PMID: 36641303.

Noel CW, Sutradhar R, Chan WC, Fu R, Philteos J, Forner D, Irish JC, Vigod S, Isenberg-Grzeda E, Coburn NG, Hallet J, Eskander A. Gaps in Depression Symptom Management for Patients With Head and Neck Cancer. Laryngoscope. 2023 Feb 7. doi: 10.1002/lary.30595. Epub ahead of print. PMID: 36748910.

Raphael J, Richard L, Lam M, Blanchette P, Leighl NB, Rodrigues G, Trudeau M, Krzyzanowska MK. Early mortality in patients with cancer treated with immune checkpoint inhibitors in routine practice. J Natl Cancer Inst. 2023 Aug 8;115(8):949-961. doi: 10.1093/jnci/djad090. PMID: 37195459.

Ruco A, Groome PA, McBride ML, Decker KM, Grunfeld E, Jiang L, Kendell C, Lofters A, Urquhart R, Vu K, Winget M. Factors Associated with the Breast Cancer Diagnostic Interval across Five Canadian Provinces: A CanIMPACT Retrospective Cohort Study. Cancers (Basel). 2023 Jan 7;15(2):404. doi: 10.3390/cancers15020404. PMID: 36672357.

Seung SJ, Saherawala H, Nguyen L, Gatley JM, Liu N, Kebabdjian M, Earle C, Klotz L, Mittmann N. Hospital encounters and associated costs of prostate evaluation for clinically important disease MRI vs. standard evaluation procedures (PRECISE) study from a provincial-payer perspective. Can Urol Assoc J. 2023 Aug;17(8):280-284. doi: 10.5489/cuaj.8197. PMID: 37581543.

Sue-Chue-Lam C, Brezden-Masley C, Sutradhar R, Yu AYX, Baxter NN. The Association of Oxaliplatin-Containing Adjuvant Chemotherapy Duration with Overall and Cancer-Specific Mortality in Individuals with Stage III Colon Cancer: A Population-Based Retrospective Cohort Study. Curr Oncol. 2023 Jul 6;30(7):6508-6532. doi: 10.3390/curroncol30070478. PMID: 37504338.

Tan VS, Tjong MC, Chan WC, Yan M, Delibasic V, Darling G, Davis LE, Doherty M, Hallet J, Kidane B, Mahar A, Mittmann N, Parmar A, Tan H, Wright FC, Coburn NG, Louie AV. Pain and Interventions in Stage IV Non-Small Cell Lung Cancer: A Province-Wide Analysis. Curr Oncol. 2023 Mar 18;30(3):3461-3472. doi: 10.3390/curroncol30030262. PMID: 36975475.

Timilshina N, Finelli A, Tomlinson G, Sander B, Alibhai SMH. Applying Quality Indicators to Examine Quality of Care During Active Surveillance in Low-Risk Prostate Cancer: A Population-Based Study. J Natl Compr Canc Netw. 2023 May;21(5):465-472.e9. doi: 10.6004/jnccn.2022.7256. PMID: 37156486.